Lot 24-8501
NAD+ · 1000mg
Research applications
- Sirtuin pathway research
- Mitochondrial electron transport
- Longevity / cellular bioenergetics
Sequence
C₂₁H₂₇N₇O₁₄P₂
Molecular weight
663.43 g/mol
Purity
≥99.0%
Abbreviation
NAD
Storage
Lyophilized: −20 °C, protected from light. Reconstituted: 2–8 °C, 7 days.
Reconstitution
Add 5 mL BAC water to a 1000 mg vial → 200 mg/mL.
NAD+
Nicotinamide adenine dinucleotide.
A central cellular cofactor for redox reactions and sirtuin/PARP activity. Researched in cellular bioenergetics, sirtuin signalling, and longevity models.
Configure
£72.00
Vial size
Lot 24-8501 · lot-matched COA included · cold-chain shipping
Qty
Research Overview
NAD+ (Nicotinamide Adenine Dinucleotide) is a central coenzyme found in all living cells. It plays a fundamental role in cellular energy metabolism and serves as a substrate for several classes of regulatory enzymes. Its decline with age has made it a major focus of longevity and metabolic research.
Sirtuin Pathway Research
NAD+ is an obligatory substrate for the sirtuin family of NAD+-dependent deacylases (SIRT1–7). Research has examined NAD+'s role in regulating sirtuin enzymatic activity, sirtuin-mediated histone deacetylation and gene expression changes, and the relationship between cellular NAD+ levels and sirtuin-dependent metabolic regulation.
PARP Activity and DNA Repair
Poly(ADP-ribose) polymerases (PARPs) consume NAD+ during DNA damage repair. Research has investigated the competition between PARP activity and sirtuin function for cellular NAD+ pools, NAD+ depletion as a consequence of DNA damage-induced PARP hyperactivation, and strategies to maintain NAD+ availability in models of genotoxic stress.
Mitochondrial Electron Transport
NAD+ and its reduced form NADH are central to mitochondrial oxidative phosphorylation. Research has examined NAD+/NADH ratio dynamics in mitochondrial function, the role of complex I in NADH oxidation and ATP generation, and mitochondrial NAD+ pools as distinct from cytosolic pools in cellular energy models.
Longevity and Cellular Bioenergetics
The decline of cellular NAD+ with age has positioned it as a key subject in longevity research, including studies of NAD+ precursor supplementation effects, the relationship between NAD+ levels and age-related metabolic dysfunction, and interactions with other longevity-associated pathways including AMPK and mTOR.
For laboratory research use only. Not intended for human or animal consumption.