Lot 24-7010
Tesamorelin · 20mg
Research applications
- Visceral adipose modulation
- Lipodystrophy models
- IGF-1 axis research
Sequence
C₂₂₁H₃₆₆N₇₂O₆₇S
Molecular weight
5135.79 g/mol
Purity
≥99.0%
Abbreviation
TESA
Storage
Lyophilized: −20 °C. Reconstituted: 2–8 °C, 7 days.
Reconstitution
Add 2 mL BAC water to a 10 mg vial → 5 mg/mL.
Tesamorelin
Stabilised GHRH(1-44) analogue.
A GHRH(1-44) analogue with an N-terminal hexenoyl modification that confers resistance to DPP-IV cleavage. Studied in visceral-adiposity and IGF-1 axis models.
Configure
£100.00
Vial size
Lot 24-7010 · lot-matched COA included · cold-chain shipping
Qty
Research Overview
Tesamorelin is a synthetic analogue of human growth-hormone-releasing hormone (GHRH) consisting of the full 44-amino-acid sequence with a trans-3-hexenoic acid group attached to the N-terminus. This modification confers resistance to DPP-IV enzymatic cleavage, extending its biological activity compared to native GHRH.
DPP-IV Resistance and Stability
The defining characteristic of Tesamorelin in research contexts is its enhanced stability. Studies have examined how the N-terminal hexenoyl modification protects against DPP-IV cleavage, the resulting extended half-life compared to unmodified GHRH analogues, and the implications for sustained GHRH receptor engagement in preclinical models.
Visceral Adipose Tissue Research
Tesamorelin has been studied in the context of visceral adiposity, particularly in relation to GH-mediated lipolysis in visceral adipose depots, IGF-1 axis stimulation and downstream metabolic effects, and lipodystrophy models where GH axis dysregulation affects fat distribution.
IGF-1 Axis Research
As a GHRH analogue, Tesamorelin stimulates endogenous GH secretion with downstream effects on IGF-1 production. Research has focused on hepatic IGF-1 synthesis in response to pulsatile GH stimulation, the IGF-1 binding protein profile under Tesamorelin-mediated GH pulses, and long-term axis dynamics in preclinical models.
For laboratory research use only. Not intended for human or animal consumption.