Fast UK dispatch · Third-party tested · Lot-matched certificates
Healing & Recovery
KPV 10mg
- Type:
- Anti-inflammatory tripeptide fragment of alpha-MSH.
- Form:
- Ready-to-use liquid solution in a 10mg research cartridge.
- Application:
- Inflammatory bowel disease and colitis models
KPV
10MG
10mg · Ready to use
£8.90 per mg · 10mg total
£89.00
Choose your pack
Lot-matched 3rd party CoA with every batch
Qty
≥99.0%
HPLC purity, verified per lot
MS
Mass-spec confirmed identity
LAL
Endotoxin tested to established limits
UK
Synthesised and tested in Britain
What's in the cartridge
Supplied as a pre-mixed liquid peptide solution in a 3ml research cartridge. Contains KPV (10mg). A tripeptide corresponding to the C-terminal fragment (residues 11–13) of alpha-MSH, studied for anti-inflammatory activity via NF-κB pathway inhibition and cytokine suppression, independent of melanocortin receptor binding.
Specifications
Format
Liquid peptide solution, 10mg
Molecular formula
Lys-Pro-Val (C16H30N4O4)
Molecular weight
342.43 g/mol
Purity
≥99.0%
Abbreviation
KPV
Vials vs Pens
11 Steps. Or one.
A vial arrives as powder: you mix it, measure it, and draw every dose by hand. The Mercia Pen arrives ready.
Traditional Vial
Mercia Pen
11 steps
mixing, measuring, drawing
1 click
dial the dose, press
~12 minutes
plus a 5 minute wait mid-way
12 seconds
ready when you are
Hand-measured
syringe markings, eyeballed
Mechanical click
the same dose, every time
Opened repeatedly
every needle re-entry is a risk
Factory-sealed
never opened, never mixed
Syringes + water
plus wipes and a sharps bin
Nothing else
everything is in the pen
Handling and storage
Store
Store immediately at 2–8°C upon delivery. Do not freeze.
Shipping
Shipped in validated temperature-controlled packaging to maintain product stability during transit.
Avoid Freezing
Do not freeze, as freezing may compromise product quality.
Temperature Tolerance
Stabilised below 25°C for delivery. Should not be exposed to higher temperatures.
3rd Party Tested
Independently tested for heavy metals, residual solvents and endotoxins to established limits.
Full Traceability
Batch-level traceability from production to delivery.
Certificate of Analysis
Lot-matched 3rd party CoA with every batch. Available on our website.
Shelf Life
12 months from manufacture when stored at 2–8°C.
What customers say
Research overview
KPV is the C-terminal tripeptide of alpha-MSH (Lys-Pro-Val), corresponding to residues 11-13 of the parent hormone. Supplied here as a UK-manufactured pre-mixed liquid peptide solution in a 3ml research cartridge, it has become a subject of research interest for its distinctive, receptor-independent anti-inflammatory mechanism.
PepT1-Mediated Cellular Uptake
Unlike classical melanocortin peptides, KPV's anti-inflammatory activity does not depend on binding to melanocortin receptors. Research published in *Gastroenterology* identified that KPV is instead transported into intestinal epithelial and immune cells via PepT1 (SLC15A1), a peptide transporter normally responsible for absorbing dietary di- and tripeptides in the small intestine. This transport mechanism is of particular research interest because PepT1 expression is upregulated in inflamed colonic tissue during inflammatory bowel disease, meaning cellular uptake of KPV is reported to concentrate preferentially where inflammation is present, rather than throughout healthy tissue uniformly.
NF-κB and MAP Kinase Inflammatory Signalling
Once inside the cell, KPV has been shown to inhibit NF-κB activation and MAP kinase inflammatory signalling at nanomolar concentrations, with a corresponding reduction in pro-inflammatory cytokine secretion in cell culture models. This dual-pathway inhibition, alongside its transporter-mediated rather than receptor-mediated entry, distinguishes KPV mechanistically from other alpha-MSH-derived research peptides that act through classical melanocortin receptor engagement.
Gastrointestinal and Colitis Research
The PepT1-uptake mechanism has been studied extensively in gastrointestinal inflammation models. Research using DSS- and TNBS-induced colitis models has reported that KPV administration reduces disease incidence and severity, alongside decreased pro-inflammatory cytokine mRNA expression and reduced histological tissue damage. A notable feature of this research is that KPV has demonstrated effectiveness when administered orally, a property uncommon among therapeutic peptides, which is attributed to its stability and active PepT1-mediated transport across the gut epithelium rather than passive diffusion.
Dermatological and Barrier Research
As a truncated fragment of alpha-MSH, KPV sits within a broader family of melanocortin-derived peptides studied for anti-inflammatory activity in dermatological research contexts, including models relevant to inflammatory skin conditions. Its barrier-relevant research also extends to gut epithelial integrity, an area of overlapping interest given PepT1's role at the intestinal barrier itself.
Research Format and Quality Assurance
Supplied as a pre-mixed liquid peptide solution with no reconstitution step, each cartridge is independently HPLC-tested for purity and confirmed for identity by mass spectrometry, with a lot-matched Certificate of Analysis issued for every order.
For laboratory research use only. Not intended for human or animal consumption.
Frequently asked questions
Is a Certificate of Analysis included?+
Yes. Every order ships with a third-party CoA matched to the lot number printed on your cartridge. A sample CoA is available on the site.
How is purity verified?+
Each batch is HPLC-tested for purity and mass-spec confirmed for identity, then tested for heavy metals, residual solvents and endotoxins.
Does the solution need reconstituting?+
No. The cartridge is supplied as a ready-to-use liquid solution in 3ml bacteriostatic water.
How is it shipped and stored?+
Validated temperature-controlled packaging, UK next-day dispatch. Store at 2–8°C on arrival, do not freeze, 12-month shelf life.
Who is this supplied to?+
Qualified personnel for in vitro laboratory research and analytical work only. Not for human or animal consumption.
